NPC Hospital, where you’re a doctor and have to deal with the massive body counts from other games.
Or a foraging game, open world style, where you have to travel to the right places during the right time of day to pick certain foods. There are lookalikes and also tons of risks like landowners with guns, pesticides, snakes, and tough terrain. I imagine it would be very much like The Hunter COTW but with plants.
Fat Bear Week: The Game. I’d set it in all the different National Parks, though, each one requiring a different strategy to become the fattest bear. No salmon? Too bad. Better find another food source.
I feel like your two line description bear-ly scratches the surface of possibilities here.
Seriously. We want to enjoy our right to Bear Arms.
Dune: Universe.