Sure, there will be examples of problems in any field that has hundreds of thousands to millions of humans working in it. That doesn’t mean there’s a broad crisis, and it doesn’t mean that most research is faked or fallible. In your 2004 example, all of the data wasn’t faked, some images for publication were doctored. There’s been potential links between alzheimer’s and aBeta amyloids since at least 1991 (1), long before this paper that posited a specific aB variant as a causal target. Additionally, other Alzheimer’s causes and treatments are also under investigation, including gut microbiome studies since at leasg 2017 (2). Finally, drugs targeting aB proteins to remove brain plaques work in preclinical trials, indicating that the 2004 paper was at least on the right track even if they cheated to get their paper published. This showcases science working well: bad-faith actors behaved unethically, but the core parts of their work were replicated and found to be effective, so some groups followed that to clinical trials which are still ongoing, and others followed other leads for a more holistic understanding of the disease.
Also, I’d very much argue that human neurological diseases are both bleeding edge and niche, which inherently means that recognizing problems in studies will take more time than something that is cheaper or faster to test and validate, but problems will eventually be recognized as this one was.
- Cras P, Kawai M, Lowery D, Gonzalez-DeWhitt P, Greenberg B, Perry G. Senile plaque neurites in Alzheimer disease accumulate amyloid precursor protein. Proc Natl Acad Sci USA. 1991;88:7552–6.
- Cattaneo, A. et al. Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly. Neurobiol. Aging 49, 60–68 (2017).
GTFO with that “politics” bullshit. It stopped being a purely political difference when Trump made it about racism, sexism, and all other possible forms of bigotry. It stopped being about purely bigotry when he tried to stage a coup.
Above and beyond, you don’t know their life. Maybe they needed a life-saving abortion and their father gleefully cackled when that right was effectively removed in many states. Maybe they’re black and their father bragged about the shootings of black folks, they’re latin and he chortled over the deportation rhetoric, or they’re Muslim and he rubbed the travel bans in their face. Maybe they have/had long COVID and their father gave it to them because “it’s a hoax.” There are so many reasons for cutting MAGA idiots out of your life and Trump’s political policy is the least of them