I had definitely thought that as well! But then I googled it and found there can be “major interactions” between Adderall and Zoloft, and that Adderall can actually affect serotonin (not sure if it promotes more serotonin or inhibits reuptake). It must be some kind of compounding effect?
But great point on the Zoloft! It seems it was definitely an OD factor, especially if there is more serotonin floating up there “naturally” and the re-uptake inhibition becomes way more effective. 😬
(I’m still actually dealing with tapering off Zoloft, but oh my gods I am so much less physically anxious already.)
Concurrent use of stimulants with antidepressants is a high-risk behavior and is medically contraindicated due to potential cytochrome P450 2D6 (CYP2D6) enzyme inhibition and a resulting increase in serotonin levels.
I don’t think Adderall affects serotonin receptors, just dopamine and some norepinephrine.
However, that tiny ass dose of Zoloft could be a huge ass dose if your body doesn’t break it down.
I had definitely thought that as well! But then I googled it and found there can be “major interactions” between Adderall and Zoloft, and that Adderall can actually affect serotonin (not sure if it promotes more serotonin or inhibits reuptake). It must be some kind of compounding effect?
But great point on the Zoloft! It seems it was definitely an OD factor, especially if there is more serotonin floating up there “naturally” and the re-uptake inhibition becomes way more effective. 😬
(I’m still actually dealing with tapering off Zoloft, but oh my gods I am so much less physically anxious already.)
I just did a quick search, and found this:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4309786/
So it was the common culprits, the P450 enzymes. I’m lucky to have not given myself serotonin syndrome many times.