This isn’t a “comic book” universe, but the parahumans story universe (Worm and Ward) fits this pretty well.
Without spoiling too much of the story, characters all get powers in response to traumatic events. The powers they get also tend to reflect the type of trauma that occurred, so if they lost an arm they might get a healing power, or if they were trapped in a burning building they might get the ability to phase through walls and a resistance to fire. All of the powers in the setting tend to follow this approach, and stay within the rules of the setting.
This isn’t a “comic book” universe, but the parahumans story universe (Worm and Ward) fits this pretty well.
Without spoiling too much of the story, characters all get powers in response to traumatic events. The powers they get also tend to reflect the type of trauma that occurred, so if they lost an arm they might get a healing power, or if they were trapped in a burning building they might get the ability to phase through walls and a resistance to fire. All of the powers in the setting tend to follow this approach, and stay within the rules of the setting.