&& flatpak update

You can also include && flatpak uninstall --unused in your alias to clean up more space.

celluloid, pix, hexchat, hypnotix, rhythmbox, LibreOffice

Those applications uninstalled just fine without any dependency issues last time I tried Mint.

If you’re unsure, make a snapshot of your current VM state (if your VM software supports it). Then just uninstall the junk you don’t need until Mint breaks. Restore snapshot, test some more, and so on.

Tip: Run sudo apt autoremove package in the terminal so you can see which dependencies that are removed.